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宿主来源
Mouse抗原名称
IL-9分子别名
Interleukin-9; Cytokine P40; T-cell growth factor P40; IL9细胞定位
SecretedAccession
P15248克隆号
S-2920抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
ICFCM
稀释度
应用 稀释度 推荐种属 ICFCM 1:2000 Hu
Interleukin-9 (IL-9) is a 14 kDa glycoprotein cytokine primarily produced by activated Th2, Th9, and innate lymphoid cells that signals through a heterodimeric receptor composed of the IL-9Rα chain and the common γ-chain, thereby activating JAK/STAT, PI3K/AKT, and MAPK pathways to exert pleiotropic effects on hematopoietic and epithelial cells, promoting mast-cell proliferation and differentiation, enhancing mucus production by goblet cells, modulating B-cell responses, and contributing to the pathogenesis of allergic asthma, atopic dermatitis, and certain hematologic malignancies, while also exerting context-dependent anti-tumor or pro-tumor activities depending on the cellular milieu.
流式分析
Flow cytometric analysis of 50ng/ml PMA, 1μg/ml Ionomycin and 1μg/ml BFA cultured human PBMC (human peripheral blood mononuclear cell) labelling human IL-9 antibody at 1/2000 dilution (0.1 μg) / (Right Panel) compared with a Mouse IgG2b, κ Isotype control (Left Panel). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 488 separately. Gated on total viable cells.
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