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宿主来源
Mouse抗原名称
CD282分子别名
Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; TIL4; TLR2Accession
O60603克隆号
S-2968抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD282, also known as Toll-like receptor 2 (TLR2), is an approximately 89-kDa type I transmembrane receptor of the Toll-like receptor family that plays a pivotal role in innate immunity by recognizing pathogen-associated molecular patterns (PAMPs) such as bacterial lipoproteins and cell wall components; it cooperates with co-receptors like LY96 and forms heterodimers with TLR1 or TLR6 to activate the MYD88- and TRAF6-dependent signaling pathway, leading to NF-κB activation, cytokine secretion, and inflammatory responses, while being abundantly expressed in peripheral blood leukocytes, especially monocytes, and involved in host defense against Gram-positive bacteria and yeast.
流式分析
Flow cytometric analysis of Human CD282 expression on Human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with Brilliant Violet 480™ Mouse Anti-Human CD14 Antibody and either Alexa Fluor® 647 Mouse IgG2a, κ Isotype Control (Left panel) or Alexa Fluor® 647 Mouse Anti-Human CD282 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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