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Alexa Fluor® 647 Rat Anti-Mouse CD197 (CCR7) Antibody (4B12)

C-C chemokine receptor type 7,C-C CKR-7,CC-CKR-7,CCR-7,Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1,EBV-induced G-protein coupled receptor 1),MIP-3 beta receptor,Cmkbr7,Ebi1,Ebi1h,Ccr7

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B5696
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Rat

  • 抗原名称

    CD197 (CCR7)

  • 分子别名

    C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; Cmkbr7; Ebi1; Ebi1h; Ccr7

  • 细胞定位

    Cell membrane

  • Accession

    P47774

  • 克隆号

    4B12

  • 抗体类型

    Rat mAb

  • 抗体同种型

    IgG2a,k

  • 反应种属 ?

    Ms

  • 阳性样本

    BALB/c mouse splenocytes

  • 纯化方式

    Protein A

  • 浓度

    0.2 mg/ml

  • 标记

    Alexa Fluor® 647

  • 性状

    Liquid

  • 缓冲体系

    PBS, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1.25μl per million cells in 100μl volume Ms
背景介绍

  • CD197, also known as CCR7, is a protein encoded by the CCR7 gene in humans and belongs to the G protein-coupled receptor family. It is a transmembrane protein with seven transmembrane domains, which is coupled with heterotrimeric G proteins to transduce signals downstream through various signaling cascades. CCR7 binds to two ligands: the chemokines CCL19 and CCL21. The main function of CCR7 is to guide immune cells to immune organs such as lymph nodes, thymus, and spleen by detecting specific chemokines secreted by these tissues. It is expressed on adaptive immune cell types, including thymocytes, naive T and B cells, regulatory T cells, central memory lymphocytes, and dendritic cells. CCR7 plays a crucial role in the maturation of dendritic cells and the trafficking of T cells within secondary lymphoid organs.

  • 流式分析

    • Flow cytometric analysis of Mouse CD197 (CCR7) expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with Phycoerythrin Rat Anti-Mouse CD3 Antibody and either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Left panel) or Alexa Fluor® 647 Rat Anti-Mouse CD197 (CCR7) Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.

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