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宿主来源
Mouse抗原名称
CD127分子别名
Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; IL7R细胞定位
Cell membraneAccession
P16871克隆号
S-R462抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood lymphocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD127, also known as the interleukin-7 receptor alpha (IL7R-α), is a type I cytokine receptor encoded by the IL7R gene in humans. It is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. CD127 is expressed on the surface of hematopoietic cells, particularly lymphoid lineage cells, and plays a crucial role in the development, survival, and function of T cells. It is involved in signaling pathways that promote cell survival and proliferation through the activation of JAK1, JAK3, STAT5, and the PI3K-AKT pathway. Additionally, CD127 exists in both membrane-bound and soluble forms, with the soluble form (sCD127) potentially having antagonistic or agonistic effects on IL-7 activity depending on the context.
流式分析
Flow cytometric analysis of Human CD127 expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 antibody and either Alexa Fluor®488 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor®488 Mouse Anti-Human CD127 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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