分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD155/PVR分子别名
Poliovirus receptor; Nectin-like protein 5 (NECL-5); PVS细胞定位
Cell membraneAccession
P15151克隆号
SKII.4抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood cells纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD155, also designated PVR (poliovirus receptor) and Necl-5, is a ~70 kDa primate-restricted type I transmembrane glycoprotein of the immunoglobulin superfamily that contains one V-type and two C2-type extracellular Ig-like domains, a 24-aa transmembrane segment and a 50-aa cytoplasmic tail; it serves as the cellular entry receptor for poliovirus, mediates cell adhesion by binding vitronectin and nectin-3, and engages immune receptors DNAM-1/CD226, CD96 and TIGIT to regulate NK-cell cytotoxicity, T-cell activation and tumor-cell recognition, while its expression—up-regulated by IFN-γ on endothelial cells and abundant on immature thymocytes, dendritic cells and epithelial/neuronal tumor cells—promotes cell migration, loss of contact inhibition and transendothelial migration.
流式分析
Flow cytometric analysis of CD155/PVR expression on human peripheral blood cells. Human peripheral blood cells were stained with either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD155/PVR Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
评论(0)