Mouse Anti-Human CD57 Antibody (S-3011)

CD57 (also designated HNK-1 or Leu-7) is not a protein per se, but a carbohydrate epitope synthesized by the enzymatic action of beta-1,3-glucuronyltransferase 1 (B3GAT1), a type-II membrane protein encoded by the B3GAT1 gene on chromosome 11q25; this enzyme transfers glucuronic acid to terminal N-acetyllactosamine to form the sulfated CD57 determinant on a variety of cell-surface proteins, lipids and chondroitin sulfate proteoglycans, conferring the antigen that marks subsets of terminally differentiated natural killer and CD8+ cytotoxic T lymphocytes, as well as certain neural and muscle cells, and is implicated in neural cell adhesion and the delineation of late-stage lymphocyte maturation.