Mouse Anti-Human CD209 Antibody (S-2881)

CD209 (also called DC-SIGN) is a C-type lectin transmembrane receptor encoded by the CD209 gene, expressed predominantly on immature dendritic cells and macrophages; its extracellular carbohydrate-recognition domain binds high-mannose glycans on a broad spectrum of pathogens—ranging from HIV-1, HCV, Ebola, Dengue and SARS-CoV to mycobacteria—thereby functioning as a pattern-recognition receptor that triggers pathogen internalization, lysosomal degradation and subsequent MHC-II-restricted antigen presentation to prime T cells, while also mediating dendritic cell rolling on ICAM-2/ICAM-3 for migration and immune-synapse formation, with polymorphisms in its neck region linked to altered susceptibility to HIV-1 and SARS severity.