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Mouse抗原名称
CD243分子别名
ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; MDR1; PGY1; ABCB1细胞定位
Cytoplasm, Cell membraneAccession
P08183克隆号
S-2907抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
HepG2纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD243, also known as multidrug resistance protein 1 (MDR1) or P-glycoprotein (P-gp), is a 170 kDa transmembrane protein that belongs to the ATP-binding cassette (ABC) transporter family. It functions as an ATP-dependent efflux pump, transporting a wide range of lipophilic compounds, including anti-cancer drugs, out of cells. This protein is expressed on various cell types, such as B cells, T cells, and NK cells, but not on monocytes. CD243 plays a significant role in multidrug resistance in cancer therapy and is involved in the transport of molecules across cellular membranes.
流式分析
Flow cytometric analysis of Human CD243 expression on HepG2 cells. Cells from the HepG2 (Human hepatocellular carcinoma epithelial cell) was stained with either Alexa Fluor® 647 Mouse IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD243 Antibody (Right panel) at 5 μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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