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宿主来源
Rat抗原名称
CD155分子别名
cd155; D7Ertd458e; Pvr细胞定位
MembraneAccession
Q91WP1克隆号
TX56抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD155, also known as Poliovirus Receptor (PVR) or Necl-5, is a type I transmembrane glycoprotein belonging to the nectin and nectin-like protein family. It is widely expressed in various tissues and is involved in multiple cellular processes. Structurally, CD155 consists of three extracellular immunoglobulin-like domains (D1-D3), with D1 being the domain recognized by the poliovirus. This protein plays a crucial role in the establishment of intercellular adherens junctions between epithelial cells. In the context of cancer, CD155 is often overexpressed in tumor cells, where it promotes cell proliferation, adhesion, invasion, and migration. Additionally, CD155 interacts with several immune receptors, such as DNAM-1 (CD226), TIGIT, and CD96, to modulate immune responses. These interactions can either enhance antitumor immunity or contribute to immune evasion, depending on the specific receptor involved. Due to its complex roles in tumor progression and immune regulation, CD155 has emerged as a promising target for cancer immunotherapy.
流式分析
Flow cytometric analysis of Mouse CD155 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD155 Antibody (Red line histogram) at 5 μg/test. The fluorescence histogram shows CD155 expression derived from CD4+CD8+ gated events with the forward and side light-scatter characteristics of viable thymocytes. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Flow cytometric analysis of Mouse CD155 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD155 Antibody (Red line histogram) at 5 μg/test. The fluorescence histogram shows CD155 expression derived from CD4+CD8- gated events with the forward and side light-scatter characteristics of viable thymocytes. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Flow cytometric analysis of Mouse CD155 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD155 Antibody (Red line histogram) at 5 μg/test. The fluorescence histogram shows CD155 expression derived from CD4-CD8+ gated events with the forward and side light-scatter characteristics of viable thymocytes. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Flow cytometric analysis of Mouse CD155 expression on BALB/c mouse thymocytes. BALB/c mouse thymocytes were stained with either Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD155 Antibody (Red line histogram) at 5 μg/test. The fluorescence histogram shows CD155 expression derived from CD4-CD8- gated events with the forward and side light-scatter characteristics of viable thymocytes. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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