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Mouse抗原名称
CD86分子别名
T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD28LG2细胞定位
Cell membraneAccession
P42081克隆号
IT2.2抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
RhMk, CyMk, Hu阳性样本
Human Peripheral Blood cells纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD86, also known as B7-2, is a co-stimulatory molecule expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation, proliferation, and differentiation. Additionally, CD86 can also bind to CTLA-4, an inhibitory receptor on T cells, thereby regulating immune responses and maintaining immune homeostasis. This dual functionality makes CD86 a key target in immunotherapy research, particularly in the development of cancer treatments and autoimmune disease management strategies.
流式分析
Flow cytometric analysis of Human Peripheral Blood cells labelling Human CD86 antibody at 1:200 (1 μg) dilution (Right panel) compared with a Mouse IgG2b, κ Isotype Control (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD14 - Allophycocyanin antibody separately.
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