Mouse Anti-Human CD95 Antibody (DX2)

CD95, also known as Fas or APO-1, is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. It is a member of the tumor necrosis factor receptor superfamily and is expressed on the surface of various immune cells, including T cells and B cells. When CD95 is engaged by its ligand, CD95L, it triggers a signaling cascade involving the recruitment of adaptor proteins such as FADD, which in turn activates caspases, leading to the dismantling of the cell. This pathway is essential for maintaining immune homeostasis by eliminating activated or damaged cells. Dysregulation of CD95 signaling has been implicated in a range of diseases, including autoimmune disorders and cancer, highlighting its importance in both physiological and pathological contexts.