Mouse Anti-Human CD325 Antibody (8C11)

CD325, also known as N-cadherin or cadherin-2, is a 130–140 kDa type I transmembrane glycoprotein belonging to the cadherin superfamily. It is a calcium-dependent cell-cell adhesion molecule that plays a crucial role in maintaining tissue architecture and regulating morphogenetic movements during development. The protein consists of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. The extracellular domains mediate homophilic interactions between adjacent cells, while the cytoplasmic tail interacts with catenin proteins, which link the cadherin complex to the actin cytoskeleton. CD325 is expressed in various tissues, including neurons, cardiac muscle, and some cancer cells, and is involved in processes such as neural development, cardiac function, and cancer metastasis.