Rat Anti-Mouse CD115 Antibody (AFS98)

CD115, also known as CSF1R or colony stimulating factor 1 receptor, is a type I transmembrane protein encoded by the c-fms gene and belongs to the type III receptor tyrosine kinase family. It is primarily expressed on cells of the monocyte/macrophage lineage, dendritic cells, and in the developing placenta. CD115 acts as a receptor for colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34), mediating the biological effects of these cytokines on the survival, proliferation, and differentiation of myeloid cells, including macrophages and osteoclasts. The receptor consists of an extracellular domain with five immunoglobulin-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain. Mutations in the CD115 gene have been associated with a predisposition to myeloid malignancies.