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宿主来源
Mouse抗原名称
CD7分子别名
T-cell antigen CD7; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41免疫原
Recombinant ProteinAccession
P09564克隆号
S-575-17抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood lymphocytes纯化方式
Protein G浓度
0.2 mg/ml标记
PE性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD7, also known as GP40, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily, primarily expressed on the surface of T cells and natural killer (NK) cells. It is highly expressed in acute T-cell leukemia (T-ALL) and certain peripheral T-cell lymphomas. CD7 plays a significant role in the regulation and activation of the immune system. It is involved in T-cell and T-cell/B-cell interactions during early lymphoid development and acts as a co-stimulatory molecule with CD3, CD45, and PI3K. CD7 has two known ligands, K12 protein and galectin-1, which can influence T cell proliferation, migration, and apoptosis. Additionally, CD7 is being explored as a target for cancer therapies, such as antibody-drug conjugates, due to its high expression in certain malignancies.
流式分析
Flow cytometric analysis of Human CD7 expression on human peripheral blood lymphocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Phycoerythrin mouse IgG1, κ Isotype Control (Left panel) or SDT PE Mouse Anti-Human CD7 Antibody (Right panel) at 1.25μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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