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宿主来源
Mouse抗原名称
CD106分子别名
Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; INCAM-100; VCAM1细胞定位
Cell membrane, SecretedAccession
P19320克隆号
S-2895抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
HUVEC treated with TNF-α纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD106, also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein encoded by the VCAM1 gene in humans and belongs to the immunoglobulin superfamily. It is a cytokine-inducible cell surface protein that mediates the adhesion of leukocytes to vascular endothelium, playing a crucial role in immune responses and inflammation. CD106 is primarily expressed on endothelial cells, but its expression can also be found in other cell types such as smooth muscle cells and mesenchymal stem cells. The upregulation of CD106 in endothelial cells is induced by cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), and it is involved in various pathological conditions, including atherosclerosis and rheumatoid arthritis. In addition, CD106 is essential for embryonic development, particularly in the formation of the umbilical cord and placenta.
流式分析
Flow cytometric analysis of CD106 expression on HUVEC cells. HUVEC were either untreated (Left Panel) or treated 20 hours with 10 ng/ml Human TNF-α protein (Right Panel) and then stained with Mouse IgG1, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Mouse Anti-Human CD106 Antibody at 1.25 μl/test (Red line histogram). Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software
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