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宿主来源
Mouse抗原名称
CD158b/j分子别名
CD158b1; KIR2DL2; CD158B1; NKAT2a; NKAT2b; CD158b2; KIR2DL3; CD158B2; KIRCL23; NKAT2; CD158j; KIR2DS2; CD158J; NKAT5细胞定位
Cell membraneAccession
P43631, P43627, P43628克隆号
S-2917抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Hu
CD158b/j, also known as KIR2DL2/L3/S2, is a member of the killer cell immunoglobulin-like receptor (KIR) family and belongs to the immunoglobulin superfamily. It is a type I membrane glycoprotein with two immunoglobulin C2-type domains. CD158b/j is expressed on natural killer (NK) cells and a subset of T cells. These receptors play a crucial role in modulating the immune response by interacting with specific HLA-C antigens on target cells, thereby inhibiting the cytotoxic functions of NK and T cells. The expression of CD158b/j on T cells increases with age, particularly in CD8 T cells, due to epigenetic changes such as DNA demethylation. This age-related expression pattern may contribute to the immune senescence observed in older individuals.
流式分析
Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human CD158b/j antibody at 1/2000 (0.1 μg) dilution. Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD56 - PE antibody separately.
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