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宿主来源
Mouse抗原名称
CD103分子别名
Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; ITGAE细胞定位
MembraneAccession
P38570克隆号
Ber-ACT8抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on tissue-resident memory T cells (T RM cells), regulatory T cells (Tregs), and certain dendritic cells. It binds to E-cadherin on epithelial cells, mediating lymphocyte adhesion and retention in tissues such as the skin, gut, and lungs. This interaction is crucial for immune surveillance and maintaining tissue integrity. CD103 expression is regulated by TGF-β, which enhances its ability to bind E-cadherin. In cancer research, CD103 is significant in tumor-infiltrating lymphocytes (TILs), influencing immune responses within tumors. Additionally, CD103 plays a role in cytotoxic T cell activation and effective tumor cell lysis.
流式分析
Flow cytometric analysis of human CD103 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD103 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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