Mouse Anti-Human CD203c Antibody (NP4D6)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3,E-NPP 3,NPP3,Alkaline phosphodiesterase I,Dinucleoside polyphosphatase,Nucleotide diphosphatase,Nucleotide pyrophosphatase (NPPase),Phosphodiesterase I beta (PD-Ibeta),Phosphodiesterase I/nucleotide pyrophosphatase 3,PDNP3,ENPP3
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宿主来源
Mouse抗原名称
CD203c分子别名
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ; E-NPP 3; NPP3; Alkaline phosphodiesterase I; Dinucleoside polyphosphatase; Nucleotide diphosphatase; Nucleotide pyrophosphatase (NPPase); Phosphodiesterase I beta (PD-Ibeta); Phosphodiesterase I/nucleotide pyrophosphatase 3; PDNP3; ENPP3细胞定位
Cell membrane, SecretedAccession
O14638克隆号
NP4D6抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD203c, also known as ectonucleotide pyrophosphatase/phosphodiesterase-3 (E-NPP3), is a type II transmembrane protein belonging to the ectonucleotide pyrophosphatase/phosphodiesterase family. It is specifically expressed on basophil-committed progenitor cells and mature basophils, and to a lesser extent on tissue mast cells. CD203c is rapidly upregulated on the cell surface upon basophil activation, such as through cross-linking of the IgE receptor, making it a valuable activation marker for these cells. It plays a role in regulating the inflammatory response by hydrolyzing ATP, which helps suppress chronic allergic inflammation. Additionally, CD203c has been identified as a potential biomarker for basophilia in diseases like chronic myeloid leukemia (CML), where its expression levels correlate with disease severity and treatment response.
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling Human CD203c antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD123 - FITC antibody separately.
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