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宿主来源
Mouse抗原名称
CD137分子别名
Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; ILA; TNFRSF9细胞定位
Cell membraneAccession
Q07011克隆号
4B4-1抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
RhMk, CyMk, Hu纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Hu
CD137, also known as 4-1BB, is a co-stimulatory molecule expressed on the surface of activated T cells and natural killer cells. It plays a crucial role in enhancing the immune response by providing additional signals that promote T cell proliferation, survival, and cytokine production. CD137 is a member of the tumor necrosis factor receptor superfamily and its ligand, CD137L, is primarily found on antigen-presenting cells. The interaction between CD137 and CD137L helps to sustain the activation of T cells and supports the development of long-lasting immune responses, making it an important target for immunotherapy in cancer treatment and other diseases where modulation of the immune system is beneficial.
流式分析
Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells), treated 48 hours with 10 μg/ml PHA (Right panel) or untreated (Left panel), labeling Human CD137 at 1/2000 dilution (0.1 μg). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD25 - Brilliant Violet 421™ antibody separately.
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