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Rabbit抗原名称
CD80分子别名
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1 (B7); CD28LG; CD28LG1; LAB7免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P33681克隆号
S-288-177抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu阳性样本
Raji纯化方式
Protein A浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD80, also known as B7-1, is a co-stimulatory molecule expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation. Additionally, CD80 can bind to CTLA-4, an inhibitory receptor on T cells, which serves as a negative regulatory mechanism to control the extent of the immune response. This dual functionality highlights the importance of CD80 in both initiating and modulating immune reactions, making it a key target in immunotherapy research for conditions such as cancer and autoimmune diseases.
流式分析
Flow cytometric analysis of Human CD80 expression on Raji. Cells from the Raji (Human Burkitt's lymphoma B lymphocyte, Right) or 293T (Human embryonic kidney epithelial cell, Left) was stained with Phycoerythrin Rabbit IgG Isotype Control (Black line histogram) and SDT FITC Rabbit Anti-Human CD80(B7-1) Antibody (Red line histogram) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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