Rat Anti-Mouse CD31 Antibody (MEC13.3)

CD31, also known as platelet endothelial cell adhesion molecule (PECAM-1), is a glycoprotein encoded by the PECAM1 gene and expressed on endothelial cells, platelets, and various types of leukocytes. It is a type I transmembrane protein with six extracellular immunoglobulin-like domains, a transmembrane segment, and a short cytoplasmic tail. CD31 plays crucial roles in cell-cell adhesion, immune response, and vascular integrity. It facilitates leukocyte transmigration during inflammation, maintains endothelial cell junctions, and regulates vascular permeability. Additionally, CD31 is involved in angiogenesis and has potential implications in cancer metastasis and thrombus formation. Its expression and function are also implicated in various diseases, including atherosclerosis and Alzheimer's disease.