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Rat抗原名称
CD86分子别名
T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD28LG2细胞定位
Cell membraneAccession
P42081克隆号
GL-1抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms纯化方式
Protein G浓度
0.2 mg/ml标记
PE-Cy7性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Ms
CD86, also known as B7-2, is a co-stimulatory molecule expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation, proliferation, and differentiation. Additionally, CD86 can also bind to CTLA-4, an inhibitory receptor on T cells, thereby regulating immune responses and maintaining immune homeostasis. This dual functionality makes CD86 a key target in immunotherapy research, particularly in the development of cancer treatments and autoimmune disease management strategies.
流式分析
Flow cytometric analysis of CD69 expression on unstimulated and stimulated Mouse splenic leukocytes. C57BL/6 Mouse splenocytes were either not stimulated (Left panel) or stimulated 3 days (Right panel) with 500 ng/ml and then stained with Brilliant Violet 421™ Rat Anti-Mouse CD19 and SDT PE-Cy7 Rat Anti-Mouse CD86 Antibody at 1.25 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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