Armenian hamster Anti-Mouse TCR γ/δ Antibody (S-2752)

The TCR γ/δ protein is a T-cell receptor (TCR) expressed on the surface of γδ T cells, consisting of a γ chain and a δ chain linked by disulfide bonds to form a heterodimer, belonging to the immunoglobulin superfamily. Unlike the conventional αβ TCR, the γδ TCR can directly recognize phosphorylated metabolites (e.g., IPP), heat shock proteins, lipid antigens, and viral proteins on pathogens or stressed cells without requiring MHC presentation, granting it broader antigen recognition capabilities. Its variable (V) region exhibits limited diversity but undergoes gene rearrangement (V-J or V-D-J) to generate restricted clonotypes. γδ T cells are predominantly localized in barrier tissues such as mucosal surfaces, skin, and the gut, playing a crucial role in early immune defense. Combining features of both innate and adaptive immunity, γδ T cells rapidly secrete cytokines (e.g., IFN-γ, TNF-α) and exert cytotoxic effects, contributing to anti-infection responses, tumor immunosurveillance, and autoimmune regulation. Their unique mechanisms make them promising targets for immunotherapy, such as CAR-γδ T cell therapies.