Mouse Anti-Human CD371 Antibody (S-2850)
C-type lectin domain family 12 member A,C-type lectin-like molecule 1 (CLL-1),Dendritic cell-associated lectin 2 (DCAL-2),Killer cell C-type lectin-like receptor L1 (hKLRL1),Myeloid inhibitory C-type lectin-like receptor (MICL),CLL1,DCAL2,KLRL1,MICL,CLEC12A
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宿主来源
Mouse抗原名称
CD371分子别名
C-type lectin domain family 12 member A; C-type lectin-like molecule 1 (CLL-1); Dendritic cell-associated lectin 2 (DCAL-2); Killer cell C-type lectin-like receptor L1 (hKLRL1); Myeloid inhibitory C-type lectin-like receptor (MICL); CLL1; DCAL2; KLRL1; MICL; CLEC12A细胞定位
Cell membraneAccession
Q5QGZ9克隆号
S-2850抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human Peripheral Blood纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD371, also known as CLEC12A, is a type II transmembrane protein with extracellular C-type lectin domains, primarily expressed on myeloid cells. It is a potential myeloid cancer stem cell marker and is considered a target for antibody-based or chimeric antigen receptor T-cell therapies. CD371 is particularly associated with DUX4-rearranged leukemia, where it is highly expressed and serves as a unique cell surface marker. Its expression is also linked to “switch” acute lymphoblastic leukemia (ALL), which has a tendency to switch to monocyte-like cells upon corticosteroid treatment.
流式分析
Flow cytometric analysis of Human Peripheral Blood labelling Human CD371 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (left panel). Goat Anti- Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD16 - APC antibody separately.
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