分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD103分子别名
Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; ITGAE细胞定位
MembraneAccession
P38570克隆号
Ber-ACT8抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on tissue-resident memory T cells (T RM cells), regulatory T cells (Tregs), and certain dendritic cells. It binds to E-cadherin on epithelial cells, mediating lymphocyte adhesion and retention in tissues such as the skin, gut, and lungs. This interaction is crucial for immune surveillance and maintaining tissue integrity. CD103 expression is regulated by TGF-β, which enhances its ability to bind E-cadherin. In cancer research, CD103 is significant in tumor-infiltrating lymphocytes (TILs), influencing immune responses within tumors. Additionally, CD103 plays a role in cytotoxic T cell activation and effective tumor cell lysis.
流式分析
Flow cytometric analysis of Human PBMC were stained with stimulated 3 days with 10 μg/ml PHA (Right panel) or unstimulated (Left panel) was stained with Brilliant Violet 421™ Mouse Anti-Human CD3 and Alexa Fluor® 647 Mouse Anti-Human CD103 Antibody at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
评论(0)