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宿主来源
Rat抗原名称
CD11b分子别名
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam细胞定位
Cell membraneAccession
P05555克隆号
M1/70抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Hu, Ms阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
APC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu，Ms
CD11b, also known as integrin alpha M (ITGAM), is a cell surface receptor belonging to the integrin family and primarily expressed on immune cells such as macrophages, monocytes, neutrophils, and NK cells. It forms a heterodimer with CD18 to create the β2 integrin complex, which is crucial for mediating cell adhesion, migration, and immune responses. CD11b plays a significant role in leukocyte recruitment and activation during inflammation and immune responses by interacting with ligands like ICAM-1 and iC3b. Additionally, it is involved in phagocytosis and immune regulation in various diseases, including cancer and autoimmune conditions.
流式分析
Flow cytometric analysis of Human CD11b expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Brilliant Violet 510™ Mouse Anti-Human CD14 antibody and either APC Rat IgG2b, κ Isotype Control (Left panel) or SDT APC Rat Anti- Human CD11b antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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