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产品规格
宿主来源
Rat抗原名称
CD19分子别名
B-lymphocyte antigen CD19; Differentiation antigen CD19细胞定位
Cell membraneAccession
P25918克隆号
1D3抗体类型
Rat mAb抗体同种型
IgG2a反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.2 mg/ml标记
PE性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Ms
背景介绍
CD19 is a 95 kDa type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is expressed on the surface of B lymphocytes and follicular dendritic cells. It plays a crucial role in B cell activation and humoral immune responses by forming a complex with CD21, CD81, and CD225. This complex reduces the threshold for B cell receptor (BCR) activation, enhancing downstream signaling pathways and facilitating B cell responses to antigens. CD19 is also a biomarker for B cell development and lymphoma diagnosis, and it is targeted in immunotherapies for diseases like leukemia.
流式分析
Flow cytometric analysis of Mouse CD19 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes cells were stained with Brilliant Violet 421™ Rat Anti-Mouse CD3 antibody and either PE Rat IgG2a, κ Isotype Control (Left panel) or SDT PE Rat Anti-Mouse CD19 antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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