Biotin Mouse Anti-Human TCR γ/δ Antibody (S-R637)

The TCR γ/δ protein is a distinctive T-cell receptor (TCR) expressed on the surface of γδ T cells, composed of a γ chain and a δ chain linked by disulfide bonds to form a heterodimer, belonging to the immunoglobulin superfamily. Unlike the conventional αβ TCR, the γδ TCR can directly recognize a broad range of antigens (e.g., phosphorylated metabolites, lipids, stress proteins) without requiring MHC presentation, granting it broader antigen specificity. Its variable (V) region diversity arises from V, (D), and J gene segment rearrangements, though it exhibits less diversity than the αβ TCR. γδ T cells are primarily found in mucosal tissues, skin, and the gut, playing crucial roles in early immune defense, tumor surveillance, and tissue repair. They can rapidly secrete cytokines (e.g., IFN-γ, IL-17) or exert cytotoxic effects, serving as key effector cells bridging innate and adaptive immunity.