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宿主来源
Mouse抗原名称
CD273分子别名
Programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; Butyrophilin B7-DC (B7-DC); B7DC; PDCD1L2; PDL2; PDCD1LG2细胞定位
Cell membraneAccession
Q9BQ51克隆号
S-R590抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human monocyte-derived mature dendritic cells纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5 μl per million cells in 100μl volume Hu
CD273, also known as B7-DC or PD-L2, is a 42 kDa type I transmembrane glycoprotein belonging to the B7 family of the immunoglobulin superfamily. It is primarily expressed in dendritic cells, liver, and a few transformed cell lines. CD273 acts as a ligand for the coinhibitory receptor PD-1 (CD279), playing a crucial role in immune regulation by inhibiting T cell activation, proliferation, and cytokine production. Unlike PD-L1, CD273 has a higher affinity for PD-1 and is particularly upregulated in the presence of Th2 cytokines such as IL-4. Additionally, CD273 can also bind to repulsive guidance molecule b (RGMb), which is involved in regulating immune responses through BMP and neogenin signaling pathways.
流式分析
Flow cytometric analysis of Human CD273 expression on human monocyte-derived mature dendritic cells. Human monocyte-derived mature dendritic cells were stained with Brilliant Violet 711™ Mouse Anti-Human CD11c Antibody and either Mouse IgG1, κ Isotype Control (Left panel) or SDT Pacific Blue Mouse Anti-Human CD273 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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