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宿主来源
Rat抗原名称
CD41分子别名
Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; Itga2b细胞定位
MembraneAccession
Q9QUM0克隆号
MWReg30抗体类型
Rat mAb抗体同种型
IgG1,k反应种属 ?
Ms阳性样本
C57BL/6 mouse platelets纯化方式
Protein G浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Ms
CD41, also known as integrin αIIb or platelet glycoprotein IIb, is a crucial protein involved in platelet aggregation and hemostasis. It is encoded by the ITGA2B gene and forms a heterodimer with integrin β3 (CD61) to create the fibrinogen receptor on platelets. This receptor is essential for platelet aggregation, as it binds soluble fibrinogen and other ligands like plasminogen, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Mutations in the CD41 gene can lead to Glanzmann thrombasthenia, a bleeding disorder characterized by prolonged bleeding after injury. CD41 is also used as a marker to identify platelets, megakaryocytes, and hematopoietic progenitor cells.
流式分析
Flow cytometric analysis of Mouse CD41 expression on C57BL/6 mouse platelets. C57BL/6 mouse platelets were stained with FITC Rat IgG1, κ Isotype Control (Black line histogram) or SDT FITC Rat Anti-Mouse CD41 Antibody (Red line histogram) at 1.25μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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