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宿主来源
Mouse抗原名称
CD105分子别名
Endoglin; END; ENG免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P17813克隆号
S-837-10抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
HeLa纯化方式
Protein A浓度
0.2 mg/ml标记
APC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD105, also known as endoglin, is a type I transmembrane glycoprotein predominantly expressed on endothelial cells and serves as an accessory receptor for the transforming growth factor-beta (TGF-β) superfamily. It plays a crucial role in angiogenesis, making it a key factor in tumor growth, survival, and metastasis. Structurally, CD105 is a homodimeric protein with a large extracellular domain, a hydrophobic transmembrane region, and a short cytoplasmic tail. Its expression is upregulated in proliferating endothelial cells, especially in tumor vessels, inflamed tissues, and during embryogenesis. Mutations in the CD105 gene are associated with hereditary hemorrhagic telangiectasia (HHT), a disorder characterized by abnormal blood vessel formation. Due to its involvement in angiogenesis, CD105 has emerged as a potential therapeutic target for cancer treatment.
流式分析
Flow cytometric analysis of Human CD105 expression on HeLa cells. Cells from the HeLa (Human cervix adenocarcinoma epithelial cell, Right) or Jurkat (Human T cell leukemia T lymphocyte, Left) cell line was stained with either APC Mouse IgG2b, κ Isotype Control (Black line histogram) or SDT APC Mouse Anti-Human CD105 antibody (Red line histogram) at 1.25 μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Flow cytometric analysis of Human CD105 expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with either APC Mouse IgG2b, κ Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD105 antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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