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宿主来源
Rat抗原名称
CD105分子别名
Endoglin; Cell surface MJ7/18 antigen; Edg; Eng细胞定位
Cell membraneAccession
Q63961克隆号
MJ7/18抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
bEnd.3. Cells纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD105, also known as Endoglin, is a type I transmembrane glycoprotein and a component of the transforming growth factor-beta (TGF-β) receptor complex. It is highly expressed in proliferating endothelial cells and plays a crucial role in angiogenesis and vascular development. CD105 is upregulated in areas of active vascular growth, such as tumor tissues, wound healing sites, and inflamed tissues, making it a valuable marker for studying tumor-related angiogenesis. Additionally, it is involved in maintaining the integrity of the vascular system and regulating immune responses. In clinical applications, CD105 is used as a diagnostic marker for certain cancers and vascular diseases, and it is also a potential target for anti-angiogenic therapies.
流式分析
Flow cytometric analysis of Mouse CD105 expression on bEnd.3. Cells from the bEnd.3 (Mouse brain endothelioma, Right) or NIH/3T3 (Mouse embryonic fibroblast, Left) was stained with either Biotin Isotype Control (Black line histogram) or SDT Biotin Rat Anti-Mouse CD105 Antibody (Red line histogram) at 5μl/test followed by Sav-iFluor 488, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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