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宿主来源
Rat抗原名称
CD11b分子别名
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Itgam细胞定位
Cell membraneAccession
P05555, P11215克隆号
S-R574抗体类型
Rat mAb抗体同种型
IgG2b,k应用
FCM反应种属 ?
Hu, Ms阳性样本
human peripheral blood cells纯化方式
Protein G浓度
0.2mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
CD11b, also known as integrin alpha M or CR3A, is a key component of the integrin family, primarily expressed on the surface of immune cells such as macrophages, monocytes, neutrophils, and natural killer cells. It forms a heterodimer with CD18 (integrin β2) to function as a receptor for various molecules, including the iC3b fragment of complement protein, fibrinogen, factor X, and ICAM-1. This receptor complex plays a crucial role in mediating cell adhesion, migration, and the uptake of pathogens and complement-coated particles. Additionally, CD11b is widely used as a marker for identifying macrophages and other immune cells in research. Its involvement in immune responses and cell signaling makes it an important target in studies related to inflammation, immune regulation, and certain diseases.
流式分析
Flow cytometric analysis of CD11b expression on human peripheral blood cells. Human peripheral blood cells were stained with PerCP-Cy5.5 Rat IgG2b, κ Isotype Control (Left panel) or SDT PerCP-Cy5.5 Rat Anti-Mouse/Human CD11b Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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