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Mouse抗原名称
CD42b分子别名
Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA免疫原
Recombinant Protein细胞定位
MembraneAccession
P07359克隆号
S-935-7抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
0.05mg/ml标记
PE性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD42b, also known as platelet glycoprotein Ib alpha chain (GPIbα), is a type I transmembrane glycoprotein with a molecular weight of approximately 145 kDa. It is encoded by the GP1BA gene and primarily expressed on the surface of platelets and megakaryocytes. CD42b forms a complex with other proteins, including CD42c (GPIbβ), CD42a (GPIX), and CD42d (GPV), which is essential for platelet adhesion and aggregation. This complex plays a crucial role in hemostasis by binding to von Willebrand factor (vWF), facilitating platelet attachment to the subendothelium at sites of vascular injury. Mutations or deficiencies in CD42b are associated with Bernard-Soulier syndrome, a rare bleeding disorder characterized by large platelets and impaired platelet function.
流式分析
Flow cytometric analysis of Human CD42b expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with APC Mouse Anti-Human CD41 Antibody and either Phycoerythrin Mouse IgG1, κ Isotype Control (Left panel) or SDT PE Mouse Anti-Human CD42b Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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