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Rat抗原名称
CD198分子别名
C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8细胞定位
Cell membraneAccession
P56484克隆号
S-R626抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
C57BL/6 mouse thymocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD198, also known as C-C chemokine receptor type 8 (CCR8), is a 41 kD G-protein coupled receptor with seven transmembrane regions. It belongs to the C-C chemokine receptor family and is expressed in various cell types, including a subset of thymocytes, Tregs, NKT cells, Th2-polarized cells, macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 plays a crucial role in mediating chemotaxis and is involved in the apoptosis of thymocytes. It is also associated with allergic inflammation and has potential as a therapeutic target for conditions like HIV-1 infection. The receptor binds to ligands such as CCL1 and CCL16 and has high affinity for viral chemokines like vMIP-I, vMIP-II, and vMCC-I.
流式分析
Flow cytometric analysis of Mouse CD198 expression on C57BL/6 mouse thymocytes. C57BL/6 mouse thymocytes were stained with Alexa Fluor® 488 Rat Anti-Mouse CD4 Antibody and either Alexa Fluor® 647 Rat IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD198 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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