分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD134分子别名
Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; TNFRSF4细胞定位
MembraneAccession
P43489克隆号
S-R589抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human peripheral blood mononuclear cells纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Hu
CD134, also known as OX40 or tumor necrosis factor receptor superfamily member 4 (TNFRSF4), is a type 1 transmembrane glycoprotein and a secondary co-stimulatory immune checkpoint molecule involved in long-term T cell immunity. It is transiently expressed on activated CD4+ and CD8+ T cells after T cell receptor (TCR) ligation. The interaction between CD134 and its ligand, OX40L, enhances T cell activation, proliferation, survival, and cytokine production. CD134 is crucial for maintaining an immune response beyond the initial activation phase and is being investigated as a target in cancer immunotherapy, autoimmune disease modulation, and vaccine development.
流式分析
Unstimulated / (Left panel) and 10 μg/ml phytohemagglutinin (PHA)-stimulated (2 days) / (Right panel) peripheral blood mononuclear cells were stained with Human CD134 at 1/200 dilution (1 μg) / (Right panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 647 antibody separately.
评论(0)