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宿主来源
Rat抗原名称
CD326分子别名
Epithelial cell adhesion molecule; Ep-CAM; Epithelial glycoprotein 314 (EGP314; mEGP314); Protein 289A; Tumor-associated calcium signal transducer 1; Tacstd1; Epcam细胞定位
Cell membraneAccession
Q99JW5克隆号
S-R627抗体类型
Rat mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse thymocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Ms |
CD326, also known as EpCAM (epithelial cell adhesion molecule) or TACSTD1 (tumor-associated calcium signal transducer 1), is a 40 kDa type I transmembrane glycoprotein that serves as a calcium-independent homophilic cell adhesion molecule in the basolateral membranes of most epithelial cells. It plays a crucial role in cell adhesion, proliferation, and differentiation, and is highly expressed in various normal epithelial tissues, such as the gastrointestinal tract and liver. However, its expression is significantly upregulated in many epithelial cancers, including colorectal, breast, and prostate cancers, making it a valuable tumor marker. In cancer biology, CD326 is involved in tumor progression, metastasis, and the maintenance of cancer stem cells. It also has potential therapeutic applications, such as targeted drug delivery and immunotherapy, due to its specific expression on cancer cells.
流式分析
Flow cytometric analysis of C57BL/6 mouse thymocytes labelling Mouse CD326 antibody at 1/200 (1 μg) dilution / (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD4 - Alexa Fluor® 647 Antibody separately.
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