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宿主来源
Rat抗原名称
CD198分子别名
C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Cmkbr8; Ter1; Ccr8细胞定位
Cell membraneAccession
P56484克隆号
S-R626抗体类型
Rat mAb抗体同种型
IgG2b,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse thymocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, -20 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Ms |
CD198, also known as C-C chemokine receptor type 8 (CCR8), is a 41 kD G protein-coupled receptor with seven transmembrane regions, belonging to the beta chemokine receptor family. It is expressed by various immune cells, including subsets of thymocytes, Tregs, NKT cells, Th2-polarized cells, macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 plays a role in mediating chemotaxis toward its ligands, such as CCL1 and CCL18, and is involved in the regulation of monocyte chemotaxis and thymic cell apoptosis. Additionally, CCR8 is associated with Th2 lymphocytes and has a role in allergic diseases. It is also considered an alternative coreceptor to CD4 for HIV-1 infection.
流式分析
Flow cytometric analysis of C57BL/6 mouse thymocytes labelling Mouse CD198 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2b, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD4 - Brilliant Violet 421™ Antibody separately.
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