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宿主来源
Rat抗原名称
CD326分子别名
Epithelial cell adhesion molecule; Ep-CAM; Epithelial glycoprotein 314; Protein 289A; Tumor-associated calcium signal transducer 1; Tacstd1; Epcam细胞定位
Cell membraneAccession
Q99JW5克隆号
S-R627抗体类型
Rat mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse thymocytes纯化方式
Protein G浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
CD326, also known as EpCAM (epithelial cell adhesion molecule) or TACSTD1 (tumor-associated calcium signal transducer 1), is a 40 kDa type I transmembrane glycoprotein that serves as a calcium-independent homophilic cell adhesion molecule in the basolateral membranes of most epithelial cells. It plays a crucial role in cell adhesion, proliferation, and differentiation, and is highly expressed in various normal epithelial tissues, such as the gastrointestinal tract and liver. However, its expression is significantly upregulated in many epithelial cancers, including colorectal, breast, and prostate cancers, making it a valuable tumor marker. In cancer biology, CD326 is involved in tumor progression, metastasis, and the maintenance of cancer stem cells. It also has potential therapeutic applications, such as targeted drug delivery and immunotherapy, due to its specific expression on cancer cells.
流式分析
Flow cytometric analysis of Mouse CD326 expression on C57BL/6 mouse thymocytes. C57BL/6 mouse thymocytes were stained with Alexa Fluor® 647 Rat Anti-Mouse CD4 Antibody and either FITC Rat IgG2a, κ Isotype Control (Left panel) or SDT FITC Rat Anti-Mouse CD326 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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