Biotin Rabbit Anti-Mouse NK1.1/CD161 Antibody (S-428-32)
Killer cell lectin-like receptor subfamily B member 1C,CD161 antigen-like family member C,Lymphocyte antigen 55c (Ly-55c),NKR-P1.9,NKR-P1C,Natural killer cell surface protein P1-40 (NKR-P1 40),CD161c,Ly55c,Nkrp1c,Klrb1c
货号： S0B5088
- 价格： ￥600
- 规格：
- 数量：
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宿主来源
Rabbit抗原名称
NK1.1/CD161分子别名
Killer cell lectin-like receptor subfamily B member 1C; CD161 antigen-like family member C; Lymphocyte antigen 55c (Ly-55c); NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40 (NKR-P1 40); CD161c; Ly55c; Nkrp1c; Klrb1c免疫原
Recombinant Protein细胞定位
MembraneAccession
P27814克隆号
S-428-32抗体类型
Recombinant mAb抗体同种型
IgG应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
NK1.1/CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor expressed as a disulfide-linked homodimer on the cell membrane. It is predominantly found on the majority of natural killer (NK) cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, particularly those with a "memory" antigenic phenotype. The expression of CD161 is specifically upregulated by IL-12 and is associated with the cytotoxic function of CD16+ NK cells. Functionally, CD161 plays a role in modulating the activation and proliferation of NK cells, inducing interferon-γ production, and releasing cytotoxic granules. When CD161 binds to its ligand LLT1, it inhibits NK cell cytotoxicity and cytokine secretion.
流式分析
Flow cytometric analysis of Mouse NK1.1/CD161 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Phycoerythrin Rat Anti-Mouse CD49b Antibody and either Biotin Isotype Control (Left panel) or SDT Biotin Rabbit Anti-Mouse NK1.1/CD161 Antibody (Right panel) at 5μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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