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宿主来源
Mouse抗原名称
CD185分子别名
C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15 (MDR-15); BLR1; MDR15; CXCR5细胞定位
Cell membraneAccession
P32302克隆号
S-R653抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
0.2mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD185, also known as CXCR5 or Burkitt lymphoma receptor 1 (BLR1), is a 42 kD G-protein coupled receptor with seven transmembrane regions. It belongs to the CXC chemokine receptor family and is a specific receptor for the CXC chemokine CXCL13. CD185 is expressed on mature B cells, follicular helper T cells (Tfh), and certain memory T cells. It plays a critical role in lymphocyte trafficking, particularly in the migration of T cells into B cell follicles of germinal centers, making it an established marker of follicular helper T cells. Additionally, CD185 is involved in B cell migration and maturation in lymph nodes and spleen. Its expression has been reported in various tissues, including human blood, salivary glands, and lymphatic organs.
流式分析
Flow cytometric analysis of Human CD185 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 Antibody and either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD185 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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