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宿主来源
Mouse抗原名称
CD185分子别名
C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1; Monocyte-derived receptor 15 (MDR-15); CXCR5; BLR1; MDR15细胞定位
Cell membraneAccession
P32302克隆号
S-R653抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Hu
CD185, also known as CXCR5 or Burkitt lymphoma receptor 1 (BLR1), is a G protein-coupled seven-transmembrane receptor that belongs to the CXC chemokine receptor family. It is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes and the spleen, and plays a crucial role in B cell migration and the development of lymph nodes and Peyer's patches. CXCR5 enables T cells to migrate to lymph node and B cell zones, which is essential for the production of high-affinity antibodies as B cells and T cells need to interact to activate the Ig class switch. This receptor is expressed on both CD4 and CD8 T cells and is often regarded as a defining marker for T Follicular Helper (Tfh) cells.
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Human CD185 antibody at 1/2000 (0.1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ Antibody separately.
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