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宿主来源
Mouse抗原名称
CD161分子别名
Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a (NKR-P1A); Natural killer cell surface protein P1A; KLRB1; CLEC5B; NKRP1A细胞定位
MembraneAccession
Q12918克隆号
S-R581抗体类型
Mouse mAb抗体同种型
IgG1,k应用
FCM反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Hu |
CD161 is a C-type lectin-like receptor and a type II transmembrane protein, widely expressed on various lymphocytes, including natural killer (NK) cells, CD4+ T cells, CD8+ T cells, and mucosal-associated invariant T (MAIT) cells. It functions as a co-stimulatory molecule, influencing T cell receptor (TCR)-dependent responses. CD161+ T cells are enriched in the gut and exhibit enhanced cytokine production. However, the exact mechanisms of CD161 are still controversial, as it may have both promoting and inhibitory roles in T cell activation. Additionally, CD161 is associated with transcriptional and functional phenotypes across different T cell lineages, with some conserved features among these subsets.
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Human CD161 Antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD4 - Brilliant Violet 421™ Antibody separately.
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