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宿主来源
Mouse抗原名称
CD195分子别名
C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CMKBR5细胞定位
Cell membraneAccession
P51681克隆号
S-R663抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein A浓度
0.05mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD195, also known as CCR5, is a G protein-coupled receptor that plays a critical role in immune responses and inflammation. It is expressed on immune cells such as T cells, monocytes, and macrophages, and binds chemokines like MIP-1α, MIP-1β, and RANTES to mediate leukocyte migration and recruitment to sites of inflammation. Additionally, CD195 is a co-receptor for HIV-1, facilitating viral entry into host cells, making it a key target in HIV research and treatment. Its involvement in various diseases, including HIV infection, cancer, and autoimmune disorders, highlights its significance in both immunology and clinical medicine.
流式分析
Flow cytometric analysis of Human CD195 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Alexa Fluor® 647 mouse IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD195 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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