Rat Anti-Mouse CD39 Antibody (S-R641)
Ectonucleoside triphosphate diphosphohydrolase 1,NTPDase 1,ATP diphosphohydrolase (ATP-DPH,ATPDase),Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1,Ecto-ATPase 1),Ecto-apyrase,Lymphoid cell activation antigen,Nucleoside triphosphate diphosphohydrolase 1 (NTPDase1),Entpd1
货号： S0B5042
- 价格： ￥600
- 规格：
- 数量：
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宿主来源
Rat抗原名称
Mouse CD39分子别名
Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ATP diphosphohydrolase (ATP-DPH; ATPDase); Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1; Ecto-ATPase 1); Ecto-apyrase; Lymphoid cell activation antigen; Nucleoside triphosphate diphosphohydrolase 1 (NTPDase1); Entpd1细胞定位
MembraneAccession
P55772克隆号
S-R641抗体类型
Rat mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Ms |
CD39 (Ectonucleoside triphosphate diphosphohydrolase-1, encoded by the ENTPD1 gene) is an ectoenzyme that hydrolyzes extracellular ATP into AMP, serving as the rate-limiting enzyme in the generation of adenosine. In the tumor microenvironment, CD39 works in concert with CD73 to ultimately produce immunosuppressive adenosine, which inhibits antitumor immune responses. CD39 is widely expressed on the surface of various immune cells, including T cells, B cells, natural killer cells, dendritic cells, and macrophages. Due to its critical role in immune suppression, CD39 has emerged as a promising target for cancer immunotherapy, with several inhibitors and antibody drugs currently under clinical investigation.
流式分析
Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD39 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2a, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD4 - Brilliant Violet 421™ Antibody separately.
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