Mouse Anti-Human CD184 Antibody (S-R635)
C-X-C chemokine receptor type 4,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor (LESTR),Lipopolysaccharide-associated protein 3 (LAP-3,LPS-associated protein 3),NPYRL,Stromal cell-derived factor 1 receptor (SDF-1 receptor),CXCR4
货号： S0B5037
- 价格： ￥600
- 规格：
- 数量：
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宿主来源
Mouse抗原名称
CD184分子别名
C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor (LESTR); Lipopolysaccharide-associated protein 3 (LAP-3; LPS-associated protein 3); NPYRL; Stromal cell-derived factor 1 receptor (SDF-1 receptor); CXCR4细胞定位
Cell membraneAccession
P61073克隆号
S-R635抗体类型
Mouse mAb抗体同种型
IgG2a,k应用
FCM反应种属 ?
Hu阳性样本
human PBMC纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Hu |
CD184, also known as CXCR4, is a G protein-coupled receptor with seven transmembrane domains that serves as the receptor for stromal cell-derived factor-1 (SDF-1, also known as CXCL12). It is widely expressed in various tissues, including peripheral blood leukocytes, spleen, thymus, bone marrow, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, and endothelial cells. CXCR4 plays crucial roles in multiple physiological processes, such as cell migration, hematopoiesis, vascularization, neural development, and wound healing. It also acts as a co-receptor for T-cell tropic strains of HIV-1, facilitating viral entry into CD4+ cells. In cancer, CXCR4 is overexpressed in many tumor types and is associated with increased invasiveness, metastasis, and poor prognosis. Additionally, CXCR4 is involved in the homing of hematopoietic stem cells to the bone marrow and the retention of aged neutrophils.
流式分析
Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Human CD184 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ Antibody separately.
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