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宿主来源
Armenian hamster抗原名称
Mouse CD48分子别名
CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2 (SLAMF2); Signaling lymphocytic activation molecule 2; sgp-60; Bcm-1细胞定位
Cell membraneAccession
P18181克隆号
HM48-1抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.05mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD48 (also known as SLAMF2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and a member of the signaling lymphocyte activation molecule (SLAM) family. It is expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. CD48 interacts with several ligands, such as CD2 and CD244 (2B4), to mediate immune cell adhesion, activation, and signaling. These interactions play crucial roles in T cell activation, NK cell cytotoxicity, and immune synapse formation. In disease contexts, CD48 expression is often upregulated in inflammatory conditions and certain cancers, such as acute myeloid leukemia (AML), where it may influence immune evasion and tumor progression. Additionally, CD48 has been identified as a potential biomarker and therapeutic target in autoimmune diseases, allergic conditions, and cancer immunotherapy.
流式分析
Flow cytometric analysis of Mouse CD48 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Armenian hamster IgG Isotype Control (Black line histogram) and SDT FITC Armenian hamster Anti-Mouse CD48 Antibody (Red line histogram) at 5μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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