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宿主来源
Armenian hamster抗原名称
Mouse CD48分子别名
CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2 (SLAMF2); Signaling lymphocytic activation molecule 2; sgp-60; Bcm-1细胞定位
Cell membraneAccession
P18181克隆号
HM48-1抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Ms
CD48 (also known as SLAMF2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and a member of the signaling lymphocyte activation molecule (SLAM) family. It is expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. CD48 interacts with several ligands, such as CD2 and CD244 (2B4), to mediate immune cell adhesion, activation, and signaling. These interactions play crucial roles in T cell activation, NK cell cytotoxicity, and immune synapse formation. In disease contexts, CD48 expression is often upregulated in inflammatory conditions and certain cancers, such as acute myeloid leukemia (AML), where it may influence immune evasion and tumor progression. Additionally, CD48 has been identified as a potential biomarker and therapeutic target in autoimmune diseases, allergic conditions, and cancer immunotherapy.
流式分析
Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD48 antibody at 1/2000 dilution (0.1 μg) / (Red line histogram) compared with a Armenian hamster IgG Isotype Control (Black line histogram) and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue line histogram). Goat Anti - Armenian hamster IgG Alexa Fluor® 488 was used as the secondary antibody.
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