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VEGF165 Recombinant Rabbit mAb (SDT-3855-114-2)

Vascular endothelial growth factor A,long form,L-VEGF,Vascular permeability factor (VPF),VEGF,VEGFA

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货号 S0B3739
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产品介绍

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产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    VEGF-A

  • 分子别名

    Vascular endothelial growth factor A, long form; L-VEGF; Vascular permeability factor (VPF); VEGF; VEGFA

  • 免疫原

    Recombinant Protein

  • 克隆号

    SDT-3855-114-2

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 反应种属 ?

    Hu, Ms

  • 预测反应种属
    (反应种属缩写表)

    Rt

  • 交叉反应

    It shows good reactivity with VEGF121 and no cross reactivity against Human TNF-α.

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 纯度

    ＞95% by HPLC

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt, 2 to 8 °C as supplied

  • 应用

    Sandwich ELISA

    CLIA

背景介绍

  • Vascular Endothelial Growth Factor A (VEGFA) is a pivotal biomarker in clinical diagnosis, primarily valued for its central role in angiogenesis and disease progression. As a key regulator of new blood vessel formation, its expression is frequently dysregulated in numerous pathologies, especially solid tumors.

    In oncology, elevated VEGFA levels in serum or tumor tissues strongly correlate with tumor growth, metastasis, and poor prognosis, making it a critical prognostic indicator. For example, in non-small cell lung cancer, VEGFA expression helps predict disease progression and assess patient outcomes. Beyond diagnosis, it serves as a predictive biomarker for anti-angiogenic therapies, such as bevacizumab, enabling personalized treatment strategies.

    Moreover, VEGFA’s diagnostic significance extends to non-neoplastic conditions, including cardiovascular diseases, diabetic retinopathy, and inflammatory disorders, where aberrant angiogenesis contributes to pathogenesis. Its detection, via immunohistochemistry or liquid biopsies, offers a minimally invasive means of disease monitoring. In summary, VEGFA is an indispensable tool in clinical diagnostics, linking disease detection, prognosis, and therapeutic guidance.

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