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Rabbit抗原名称
TROP2分子别名
Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1; GA733-1; M1S1; TACSTD2免疫原
Recombinant ProteinAccession
P09758克隆号
SDT-2963-19抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu交叉反应
No cross-reactivity against Trop1, CEA, CK18 fragment.
纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt, 2 to 8 °C as supplied
应用
Sandwich ELISA
Soluble TROP2 (soluble trophoblast cell-surface antigen 2) is the shed extracellular domain of the transmembrane protein TROP2, typically released from tumor cells via ADAM10 protease cleavage. It is highly expressed in various epithelial cancers, where its detection in serum or plasma is used as a potential diagnostic marker. Produced by the cleavage of membrane-bound TROP2 by ADAM10 at the R87-T88 site, which acts as an activator switch for cancer growth. oluble TROP2 is involved in regulating cancer cell proliferation, invasion, and metastatic spread. High levels of TROP2 (both membrane-bound and shed) are associated with poor prognosis and tumor progression in cancers such as breast, lung, pancreatic, and colorectal cancer.
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